Case Studies

Cancer Research Studies

Novel Mechanism of Cannabidiol-Induced Apoptosis in Breast Cancer Cell Lines

Studies have emphasized an am antineoplastic effect on the non-psychoactive, phyto-cannabinoid, Cannabidiol (CBD). However, the molecular mechanism underlying its antitumor activity is not fully elucidated. Herin, we have examined the effect of CBD on two different human breast cancer cell lines.

Peripherally Restricted Cannabinoid 1 Receptor Agonist as a Novel Analgesic in Cancer-Induced Bone Pain

Many malignant cancers, including breast cancer, have a propensity to invade bones, leading to excruciating bone pain. Opioids are the primary analgesics used to alleviate this cancer-induced bone pain (CIBP) but are associated with numerous severe side effects, including enhanced bone degradation, which significantly impairs patients’ quality of life. By contrast, agonists activating only peripheral CB1 receptors (CB1Rs) have been shown to effectively alleviate multiple chronic pain conditions with limited side effects.

Identification of Synergistic Interaction Between Cannabis-Derived Compounds for Cytotoxic Activity in Colorectal Cancer Cell Lines and Colon Polyps That Induces Apoptosis-Related Cell Death and Distinct Gene Expression

Colorectal cancer remains the third most common cancer diagnosis and fourth leading cause of cancer-related mortality worldwide. Purified cannabinoids have been reported to prevent proliferation, metastasis, and induce apoptosis in a variety of cancer cell types. This study was aimed to specify the cytotoxic effects of C. sativa-derived extracts on colon cancer cells and adenomatous polyps by identification of active compounds and characterization of their interaction

Diabetes and Asthma Research Studies

Efficacy and Safety of Cannabidiol and Tretrahydrocannabicarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study

Cannabidiol (CBD) and Tetrahydrocannabivarin (THCV) are nonpsychoactive phytocannabinoids affecting lipid and glucose metabolism in animal models. This study set out to examine the effects of these compounds in patients with type 2 diabetes.

Evaluation of Serum Cytokines Levels and the Roles of Cannabidiol Treatment in Animal Model Asthma

Studies have demonstrated the presence of T-helper 2 lymphocytes in the lung of patients with asthma. These cells are involved in the cytokine production that regulates immunoglobulin synthesis. The aim of this study was to evaluate the anti-inflammatory potential of cannabidiol (CBD) in this setting.

Neurologic Research Studies

Structure-Activity Relationship of Cannabis Derived Compounds for the Treatment of Neuronal Activity-Related Diseases

The benefits related to cannabis use in PwMS are still under investigation. However, data indicates that cannabis, with 1:1 or greater CBD;THC ratio, reduces muscle spasticity and pain in PwMS

Cannabidiol to Improve Mobility in People with Multiple Sclerosis

Studies have demonstrated the presence of T-helper 2 lymphocytes in the lung of patients with asthma. These cells are involved in the cytokine production that regulates immunoglobulin synthesis. The aim of this study was to evaluate the anti-inflammatory potential of cannabidiol (CBD) in this setting.

The Therapeutic Potential of the Phytocannabinoid Cannabidiol for Alzheimer’s Disease

 The phytocannabinoid cannabidiol (CBD) possesses neuroprotective, antioxidant and anti-inflammatory properties and reduces amyloid-B production and tau hyperphosphorylation in vitro.

Chronic Pain Research Studies

The Use of Cannabinoids in Colitis: A Systematic Review and Meta-Analysis

Clinical trials investigating the use of cannabinoid drugs for the treatment of intestinal inflammation are anticipated secondary to preclinical literature demonstrating efficacy in reducing inflammation.

Allodynia Lowering Induced by Cannabinoids and Endocannabinoids (ALICE)

Neuropathic pain is a neurological disorder that strongly affects the quality of life of patients. The molecular and cellular mechanisms at the basis of the neuropathic pain establishment still need to be clarified. Among the neuromodulators that play a role in the pathological pain pathways, endocannabinoids could be deeply involved in both neuronal and non-neuronal mechanisms responsible for the appearance of tactile allodynia.

A Peripherally Restricted Cannabinoid Receptor Agonist Produces Robust Anti-Nociceptive Effects in Rodent Models of Inflammatory and Neuropathic Pain

Cannabinoids are analgesic in man, but their use is limited by their psychoactive properties. One way to avoid cannabinoid receptor subtype 1 (CB1R)-mediated central side-effects is to develop CB1R agonists with limited CNS penetration. Activation or peripheral CB1Rs has been proposed to be analgesic, but the relative contribution of peripheral CB1Rs to the analgesic effects of systemic cannabinoids remains unclear. Here we addressed this by exploring the analgesic properties and site of action AZ11713908, a peripherally restricted CB1R agonist, in rodent pain models.

In Vitro Model of Neuroinflammation: Efficacy of Cannabigerol, A Non-Psychoactive Cannabinoid

Inflammation and oxidative stress play main roles in neurodegeneration. Interestingly, different natural compounds may be able to exert neuroprotective actions against inflammation and oxidative stress, protecting from neuronal loss. Among these natural sources, Cannabis Sativa represents a reservoir of compounds exerting beneficial properties, including cannabigerol (CBG), whose antioxidant properties have already been demonstrated in macrophages.

Cannabinoids in the Management of Difficult to Treat Pain

This article reviews recent research on cannabinoid analgesia via the endocannabinoid system and non-receptor mechanisms, as well as randomized clinical trials employing cannabinoids in pain treatment.

Cannabinoids as Novel Anti-Inflammatory Drugs

Cannabinoid receptors include CB1, which is predominantly expressed in the brain, and CB2, which is primarily found in the cells of the immune system. Manipulation of endocannabinoids and/or use of exogenous cannabinoids in vivo can constitute a potent treatment modality agianst inflammatory disorders.

Substance Abuse Research Studies

Cannabidiol Regulation of Emotion and Emotional Memory Processing: Relevance for Treating Anxiety-Related and Substance Abuse Disorders

Studies show that cannabidiol, the main non-psychotomimetic phytocannabinoid found in Cannabis sativa, reduces anxiety via 5-HT and (indirect) cannabinoid receptor activation in paradigms assessing innate responses to threat.

Early Phase in the Development of Cannabidiol as a Treatment for Addiction: Opioid Relapse Takes Initial Center Stage

Whereas Tetracannabinol hs been well documented to be rewarding and to enhance sensitivity to other drugs, cannabidiol (CBD), in contrast, appears to have low reinforcing properties with limited abuse potential and to inhibit drug-seeking behavior.

Social and Economic Studies

Economic and Social Costs of Legalized Marijuana

The Centennial Institute at Colorado Christian University commissioned this study to better understand the economic and social costs of legalized marijuana. While much has been written about the tax revenue and total sales generated from commercial marijuana, there has been little research to understand how Coloradans are paying to mitigate the consequences of commercial marijuana.Studies show that cannabidiol, the main non-psychotomimetic phytocannabinoid found in Cannabis sativa, reduces anxiety via 5-HT and (indirect) cannabinoid receptor activation in paradigms assessing innate responses to threat.